In detail, circ-CCDC66 regulated 11 miRNAs (green: hsa-miR-4326, hsamiR-146a-3p, hsa-miR-19a-5p, hsa-miR-19b-1-5p, hsa-miR-200a-3p, hsa-miR-3913-3p, hsa-miR-452-5p, hsa-miR-4773, hsa-miR-93-3p, hsa-miR-93-5p, and hsa-miR-5186) and 15 mRNAs (blue: NR4A3, ARRB1, SMAD4, CADM2, NKIRAS1, IQSEC1, EPHA7, ANKRD33B, ZBTB39, ZNF107, SLC29A2, GINS4, CCND1, POLQ, and ENPP5) in CRC. The gene discussed is SMAD4; the disease is colorectal carcinoma.