We constructed DEN/CCl4-induced Tfap2aΔMΦ mice and found that the induced Tfap2aΔMΦ mouse liver showed more tumor nodules (Fig. 3G, H), and the tumor-to-liver area ratio was increased (Fig. 3I), but DEN/CCl4-induced WT and Tfap2a knockout mice had no difference in body weight (Fig. 3J). Here, TFAP2A is linked to neoplasm.