We found that AP-2α can directly bind to the promoters of SREBP1/ACC/FASN genes and inhibit their transcription and protein levels in HCC cells, leading to a reduction in hepatic fatty acid synthesis and excessive accumulation of lipid droplets (Fig. 7D), suggesting that de novo FA synthesis in steatotic hepatocytes is directly mediated by AP-2α. The gene discussed is FASN; the disease is hepatocellular carcinoma.