TNKS and cancer: Both isoforms play a critical role in promoting the degradation of Axin through the ubiquitin-proteasome pathway, which in turn activates the Wnt signaling pathway.691,692 The inhibition of Tankyrase has been shown to impede tumor progression, making it a promising target in cancer therapy.693–701 XAV939, a well-known Tankyrase inhibitor, functions by inhibiting Tankyrase 1 and 2, thereby stabilizing Axin and promoting the degradation of β-catenin.