SOX4 and neoplasm: ICG-001 alone substantially inhibited both anchorage-dependent and -independent growth of various PDAC lines, and its combination with gemcitabine further enhanced growth inhibition in vitro.710 Moreover, the combined use of Pyrvinium and paclitaxel significantly curbed tumor growth.706 Knockdown of the Wnt pathway transcription factor SOX4 in BT-549 cells resulted in reduced proliferation and migration, while combined treatment with iCRT-3 and SOX4 knockdown synergistically inhibited cell proliferation and induced apoptosis.727