Mologni and colleagues found that the β-catenin/TCF inhibitors PKF115-584 and pyrvinium pamoate effectively blocked β-catenin-dependent transcription and synergized with a KRAS inhibitor in colon cancer cells driven by Wnt and KRAS oncogenic signaling.744 However, this combination was ineffective in colon cancer cells harboring BRAF mutations. Here, KRAS is linked to malignant colon neoplasm.