Knocking down Axin-2 upregulates Wnt/β-catenin signaling, which protects mitochondrial function, promotes dopaminergic neurogenesis, and improves behavioral function in PD rats.479 These findings underscore the critical role of Wnt signaling in dopaminergic neurogenesis and point to its potential as a therapeutic target for PD. Here, AXIN2 is linked to Parkinson disease.