In HCC, Wnt/β-catenin overactivation is detected in approximately 95% of cases, largely driven by gain-of-function mutations in the CTNNB1 gene.613 This aberrant signaling may be influenced by genetic factors, epigenetic changes (such as WIF-1 gene promoter hypermethylation), and viral infections. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.