SFRP1 and neoplasm: GLI1 induces sFRP-1 expression in gastric cancer cell lines, where Hh signaling upregulates sFRP-1 to inhibit Wnt signaling.199,200 Ma et al. explored the roles of SHH and Wnt in tumor regeneration following radiotherapy and discovered that Wnt signaling was suppressed, as evidenced by low levels of activated nuclear β-catenin, while Hh, GLI1, and sFRP-1 levels were elevated.201 This indicates that SHH activation downregulates Wnt signaling, facilitating tumor cell line regeneration.