CTNNB1 and acute myeloid leukemia: GSK3β, another principal component of the destruction complex, has been shown to drive hematopoietic stem cells into a precancerous state when deleted, and its deletion promotes acute myeloid leukemia (AML) progression when GSK3A is absent.301 Activating mutations in β-catenin (encoded by CTNNB1) are also central to cancer progression.