Additionally, enhanced Wnt signaling induces the oncogenic transformation of human mammary epithelial cells through a Notch-dependent mechanism, and Notch inhibitors can prevent this transformation, underscoring the necessity of Wnt/Notch interactions in disease progression.177,178 Notch2 is known to control Wnt signaling in leukemia, and Notch2 activation within the microenvironment is necessary for canonical Wnt signaling activation in tumor cells.179 A thorough understanding of these pathway interactions is essential for the development of targeted therapeutic strategies. The gene discussed is NOTCH2; the disease is leukemia.