These pathway alterations are intricately linked to tumor proliferation and the evasion of apoptosis.332 Wnt signaling is essential for preserving the CD34+ CSC phenotype, with β-catenin loss leading to the depletion of CD34+ CSCs and complete tumor regression.333 In both mouse and human lung adenocarcinomas, two distinct cell subpopulations have been identified: one characterized by elevated Wnt signaling and the other forming a niche that supplies Wnt ligands. The gene discussed is CD34; the disease is lung adenocarcinoma.