Atherosclerosis is a major driver of various cardiovascular diseases, including ischemia, myocardial infarction, and stroke.406 Wnt signaling is involved in all stages of atherosclerosis, from endothelial dysfunction to plaque formation.407,408 A previous study revealed that Wnt4 mediates the effects of circUSP36 on endothelial cell behavior.409 Mechanistically, circUSP36 promotes Wnt4 expression by binding competitively to miR-637, which exacerbates endothelial dysfunction in atherosclerosis. This evidence concerns the gene WNT4 and cardiovascular disorder.