WNT16 and systemic lupus erythematosus: Systemic lupus erythematosus (SLE) is a highly heritable autoimmune disorder characterized by the loss of self-tolerance, leading to the formation of nuclear autoantigens and immune complexes, affecting various organs, including the kidneys, skin, and nervous system.575 A whole-genome sequencing study on a Chinese family identified a rare missense variant of Wnt16 associated with SLE.