Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling by inhibiting GSK3β via YTHDF2 and STEAP3, promoting CRC progression.611 Another study identified lncRNA RP11-417E7.1 as a driver of M2 macrophage polarization, fostering a pro-metastatic environment by activating the Wnt/β-catenin pathway in CRC.612 Moreover, m6A-modified BACE1-AS activates Wnt signaling in a TUFT1-dependent manner, promoting CSLC traits and liver metastasis in CRC.154. Here, BACE1 is linked to colorectal carcinoma.