In mouse models of obesity-induced cognitive impairment, Wnt/β-catenin signaling mediates the regulation of FABP4, reducing neuroinflammation and cognitive decline.547 Gao et al. found that activation of canonical Wnt signaling enables embelin to suppress adipogenesis and improve glucose tolerance impaired by obesity.548 Additionally, Yue et al. identified that DHA-enriched phosphatidylcholine mitigates obesity-related osteoporosis by upregulating the Wnt/β-catenin pathway.549 Collectively, these findings provide promising avenues for addressing obesity and its complications. The gene discussed is FABP4; the disease is obesity due to melanocortin 4 receptor deficiency.