Significant loci not listed in the EWAS catalog (P < 1×10−5) identified in the TWIST EWAS included sites mapping to TSPAN5, which regulates tumour suppressor gene expression30; USP42, involved in head and neck cancer pathogenesis31; and SST, encoding somatostatin, a hormone implicated in the development of pancreatic cancer32. This evidence concerns the gene TSPAN5 and head and neck cancer.