Significant loci not listed in the EWAS catalog (P < 1×10−5) identified in the TWIST EWAS included sites mapping to TSPAN5, which regulates tumour suppressor gene expression30; USP42, involved in head and neck cancer pathogenesis31; and SST, encoding somatostatin, a hormone implicated in the development of pancreatic cancer32. Here, SST is linked to head and neck cancer.