When the scrotum of Trpv1−/− mice was exposed to a 42 °C hot water bath, spermatogenic apoptosis increased, indicating that TRPV1 inhibits spermatogenic apoptosis under 42 °C thermal stimulation [45], which was contrary to our findings that TRPV1 could promote spermatogenic apoptosis under cryptorchidism. This evidence concerns the gene TRPV1 and cryptorchidism.