However, this finding was disputed in a subsequent study using five different lines of mutant SOD1-ALS mice that neither haploinsufficiency of PERK nor deficiency of GADD34, a protein induced by ATF4 during the ISR and that stimulates autophagy [119], ameliorates neuropathology or disease course [120]. The gene discussed is EIF2AK3; the disease is amyotrophic lateral sclerosis.