CYP1B1 and osteoarthritis: In this study, it was found that osteoarthritis downregulates ALKBH5 eraser and increases CYP1B1 mRNA stability (guided by IGF2BP1 reader), thereby enhancing mesenchymal stem cell (MSC) senescence which are precursor cells differentiating to both osteoblasts and chondroblasts (impaired cartilage and bone formation) [192].