MYC and cancer: Out of all genomic regions, the ∼500-kb super-enhancer region on 8q24 that regulates MYC expression carries the largest burden of population-level cancer susceptibility (Sur et al, 2013; Buniello et al, 2019); it contains several common alleles that increase the risk for multiple major forms of human cancer (Gudmundsson et al, 2007, 2009, 2012; Yeager et al, 2009; Buniello et al, 2019).