,45 Consistent with the pathogenic role of activation of the CGAS-STING1 pathway, deletion of the Mb21d1, Sting1, or Irf3 gene abrogated the induction of the interferon 1 response and improved survival and cardiac remodeling in a mouse model of myocardial infarction.35 Here, STING1 is linked to myocardial infarction.