,43 Moreover, an increased expression level of phospho-H2A.X variant histone (pH2AFX), a marker of DSBs, in cardiac myocytes has been reported in a mouse model of lamin A (LMNA), TMEM43, and plakophilin 2 cardiomyopathy.41, 42, 43,54 Collectively, the data support the presence of DNA damage, including strand breaks in cardiomyopathies not only in cardiac myocytes but also in cardiac fibroblasts in multiple genetic models and human hearts. Here, TMEM43 is linked to cardiomyopathy.