,30 Genetic mutations also provide additional clues to the biological functions of STING1 as the gain-of-function mutations in the TMEM173 gene, encoding STING1, cause “STING-associated vasculopathy with onset in infancy,” which is an autoinflammatory disease and in part independent of activation of the IRF3.31 This evidence concerns the gene STING1 and vascular disorder.