To clarify the relationship between ApoE and MTP activity, we suppressed its function using the MTP inhibitor (MTPi) lomitapide in human hepatoma Huh-7.5 cells, a HuH-7 subline highly active in lipid metabolism (33), in the presence or absence of oleic acid (OA) that stimulates VLDL secretion (34). Here, APOE is linked to hepatocellular carcinoma.