In this observational study including 50 critically ill patients, no earlydifferences were identified in the expression of IRS1, IRS2,SLC2A1, and SLC2A4 between patients with or without DM.However, it is noteworthy that IRS1, a key gene related to cellularglucose metabolism, was downregulated in patients with stress-inducedhyperglycemia. The gene discussed is IRS2; the disease is diabetes mellitus.