In conclusion, no significant changes were found in skeletal muscle gene expressionof IRS1, IRS2, SLC2A1, and SLC2A4 in criticallyill patients with or without DM, but interestingly, stress-induced hyperglycemiadownregulated IRS1. Research focused on gene expression representsa valuable contribution to elucidate the impact of certain genes and pathways on theoutcomes of critically ill patients with DM. Here, IRS2 is linked to diabetes mellitus.