In contrast, variants in genes most common in age-related CH, DNMT3A and TET2, were relatively infrequent (3 of 144, 2.1%, and 4 of 144, 2.8%, respectively) and occurred at median age of 59 years (range 47–70), generally in line with their occurrence in the general population (27–29) (Figure 6 and Supplemental Figure 3). This evidence concerns the gene TET2 and cyclic hematopoiesis.