Given the clear role of NLRP3‐mediated pyroptosis in the SLE pathophysiology and its associated complications and the high expression of pyroptosis inflammatory effectors IL‐1β and IL‐18 in SLE patients, it is reasonable to conclude that chondrocyte pyroptosis may be involved in the pathological process of SLE‐induced hip AC degeneration and arthritis progression. Here, NLRP3 is linked to systemic lupus erythematosus.