These findings establish a novel mechanistic link between SLE and hip arthritis progression, demonstrating that SLE promotes chondrocyte pyroptosis to exacerbate AC degeneration via NF‐κB activation, highlighting chondrocyte pyroptosis as a key driver of SLE‐associated hip arthritis and a potential therapeutic target for mitigating SLE‐induced joint manifestations. Here, NFKB1 is linked to systemic lupus erythematosus.