In view of the heightened expression of inflammatory factors, especially IL‐1β and IL‐18, which are key downstream effectors of pyroptosis, observed in the cartilage of SLE‐affected mice [18, 19], as well as in the progression of arthritis [39], we further investigated the activation of pyroptotic pathways in the cartilage of SLE‐affected mice by examining the expression of key pyroptosis‐related proteins, including NLRP3, ASC, CASPASE‐1 and GSDMD. This evidence concerns the gene IL18 and systemic lupus erythematosus.