Our findings reveal that SLE not only impairs chondrocyte proliferation and promotes apoptosis but crucially triggers NLRP3‐mediated pyroptosis via NF‐κB pathway activation, thereby triggering a cascade of excessive inflammatory cytokine release and ECM degradation that specifically perpetuates joint damage in SLE‐associated arthritis. Here, NFKB1 is linked to systemic lupus erythematosus.