Conversely, certain members of the LOX family exhibited protective effects in specific tumours, such as LOX in OS for UVM, LOXL1 in OS, DSS and PFI for PCPG, LOXL3 and LOXL4 in OS, DSS and PFI for SKCM, LOXL3 in PFI for OV, LOXL4 in OS, DSS and PFI for PRAD, LOXL4 in OS for LAML, and LOXL4 in PFI for THYM and UCS (Figure 1E–I). The gene discussed is LOXL4; the disease is neoplasm.