Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the C-type lectin receptor signaling pathway is the main pathway involved in the anti-AD effects of Kochiae Fructus, which interacts with a notably larger number of anti-AD core targets and plays a direct role in intensifying crucial inflammatory and immune responses in the heart of AD pathogenesis. This evidence concerns the gene CLEC4D and Alzheimer disease.