Protein-protein interaction (PPI) networks and Molecular Complex Detection (MCODE) analyses highlighted 78 anti-AD key targets, including SRC, MAPK3, MAPK1, JUN, PIK3CA, ESR1, PTGS2, PTPN11, IL-6, and ALOX5, among the top ten anti-AD core targets. The gene discussed is PIK3CA; the disease is Alzheimer disease.