The multivariate ROC curve analysis demonstrated that SH3D21 expression possessed predictive value for one-year (AUC = 0.764), three-year (AUC = 0.750) and five-year (AUC = 0.752) survival rates in HCC patients (Fig 9C), the fitting curve revealed that the model had good reliability. This evidence concerns the gene MNMIP1 and hepatocellular carcinoma.