In the analysis of HCC samples from the TCGA database, SH3D21 was found to be highly expressed in HCC, and the increased expression of SH3D21 was positively correlated with the histological grade, clinical stage, and T stage of HCC, thereby suggesting that SH3D21 has a key role in promoting the clinical progression of HCC. Here, MNMIP1 is linked to hepatocellular carcinoma.