To ensure the reliability of our data, we used in vitro A549 lung adenocarcinoma and MDA-MB-231 breast cancer triple-negative cell cultures to demonstrate the herb extract’s effects on PI3K and Akt enzymes and clarify how PI3K/Akt/mTOR mediation regulates TNFα, VEGFα, COX-2, MMP-2, and Caspase-3. Here, PTGS2 is linked to lung adenocarcinoma.