Of note, variants (e.g., E167K), in both the transmembrane 6 superfamily member 2 (TM6SF2) gene, that regulate the assembly and secretion of VLDL, and polymorphisms of the membrane‐bound O‐acyltransferase domain containing 7 (MBOAT7) gene, which influences phospholipid metabolism, have also been associated with an increased risk of MASLD and its progression to more severe forms, including fibrosis and steatohepatitis [54]. Here, TM6SF2 is linked to metabolic dysfunction-associated steatotic liver disease.