In contrast to the low-grade dysplasia observed in Apc-deficient colon epithelium, epithelium with both Apc and Sox9 inactivation exhibited pronounced thickening, a notable increase in crypt fission and branching, and prominent nuclear atypia and multifocal cribriform glandular architecture, which are characteristics of high-grade neoplasia. Here, SOX9 is linked to neoplasm.