Furthermore, Sox9 deletion increased the incidence of metastasis, with 6 of 11 AKPS mice harboring lymph node and liver metastases, and 1 of 11 mice having a lung metastasis, compared with only 2 of 11 AKP mice with lymph node metastases and 1 of 11 AKP mice with liver and lung metastases (Supplemental Table 3). The gene discussed is SOX9; the disease is metastatic malignant neoplasm in the lymph nodes.