We found SOX2 was expressed in 13% of 92 independent colon tumors obtained from 10 AKP mice, but not in adjacent normal colon epithelium, and SOX2 expression was linked to high tumor grade (P < 0.0001) and invasiveness (P < 0.0001), suggesting a role for increased SOX2 in mouse CRC progression (Supplemental Figure 7 and Supplemental Table 2). This evidence concerns the gene SOX2 and neoplasm.