For instance, in published work, downregulation of endogenous SOX9 expression via knockdown approaches in human CRC cell lines and in neoplastic mouse organoids was reported to impair cell growth and induce differentiation, accompanied by reduced expression of stem cell markers (mainly Lgr5, Ascl2, Prom1, and Lrig1) (17). Here, LRIG1 is linked to colorectal carcinoma.