CXCL3 and colorectal carcinoma: Flow cytometry was used to detect MDSCs in the orthotopic implanted CRC mouse model, consistent with previous research, in which tumors of mice fed 4-HPA contained a markedly higher abundance of PMN-MDSC cells, and knockdown of Cxcl3 eliminated the promoting effect of 4-HPA on PMN-MDSC cells.