We applied MultiMap PLP to probe the off-state of the EGFR neighborhoodby conjugating EY onto the therapeutic antibody cetuximab that competeswith EGF.238 We identified 29 high-confidenceneighbors including a phosphatase PTPRF capable of dephosphorylatingthe EGFR, as well as some tumor promoters and tumor suppressors. Here, EGF is linked to neoplasm.