Use of the Lrig1-CreERT2/+;Apcfl/+ mouse model, which results in inducible Wnt-driven distal colonic tumor formation, could complement the present study to determine the role of DPEP1 in a tumorigenic cascade that is biased toward an MSS fate, in contrast with the AOM/DSS model which is more inflammatory in nature (62, 63). Here, DPEP1 is linked to infectious otitis media.