DPEP1 and colonic neoplasm: Based on our data connecting DPEP1 to neutrophils and MSS CRC, we utilized an azoxymethane/dextran sodium sulfate (AOM/DSS) model of colonic tumor formation in wild-type (WT) and Dpep1–/– (DPEP1-KO) C57BL/6 mice to understand the dynamics of DPEP1 in relation to histological features and immune cell recruitment (16).