We speculate that DPEP1 expression restricts tumor development toward canonical Wnt signaling–dependent, stem cell–driven tumor formation akin to CMS2, whereas its absence leads to the development of a different CRC subtype that is reminiscent of metaplastic sessile serrated lesions developing into a plaque-like MSI-H CRC, akin to CMS1 (28, 44, 53). This evidence concerns the gene DPEP1 and colorectal carcinoma.