DPEP1 immunoreactivity increased to 71% of CRCs upon analysis of a CRC TMA (Supplemental Figure 1, E and F), with its presence at the apical surface often associated with an accumulation of neutrophils in the lumen, so-called “dirty necrosis” (Figure 1B) (32–34). This evidence concerns the gene DPEP1 and colorectal carcinoma.