To elucidate the functional role of ITIH2 in lung cancer cells, we used shRNAs to deplete ITIH2 in murine mesenchymal-like lung cancer cells (344SQ, 344LN, and 531LN2) (Figure 2A and Supplemental Figure 2, A, D, and G) (24). The gene discussed is ITIH2; the disease is lung carcinoma.