Pathways related to protein degradation were affected in male WSB/EiJ mice due to dysregulation of proteasome 20S subunit genes (Psma3, Psma5, Psma6, Psma7, Psmb3, Psmb5, Psmb6, Psmd10, Psmd13, Psmd14) including chaperone-mediated autophagy signaling (Z = 2.121, p = 0.0165), cachexia signaling (Z = −3.162, p < 0.001), and microautophagy signaling (Z = −3.162, p < 0.001) (Figs. 6, 8). This evidence concerns the gene PSMA6 and Cachexia.