Variants in genes such as PICALM, H2BW1, ALDH1A1 and APOE-ε3 showed a protective association, whereas variants in the SNCA, NR4A2, PRKN, PLA2G6, GBA, APOE-ε4, MTFHR and LRRK2 genes exhibited a major risk association for idiopathic PD in populations from Mexico, Brazil, Colombia and LARGE-PD consortia cohort. The gene discussed is LRRK2; the disease is Parkinson disease.