SNP-type genetic variants showed a significant protective association against idiopathic PD in genes such as PICALM (rs3851179) in the Brazilian population, H2BW1 (rs525496) in the LARGE-PD and replication cohort (XWAS), ALDH1A1 (rs3764435) and APOE-e3 in the Mexican population. Here, PICALM is linked to Parkinson disease.