LRRK2 and Parkinson disease: Furthermore, this review outlines the overlap of pathophysiological pathways with other clinical entities, underscoring their shared genetic loci as monogenetic PD variants such as PARK1, PARK2, PARK8 and PARK14 share SNCA, PRKN, LRRK2 and PLA2G6 loci respectively with idiopathic PD (although not the exact variants) [52, 53].