The distribution of risk scores, survival time and expression levels of six genes in different groups were showed in Fig. 2D. In the high-risk group, the mortality status was more intensive with high expression of KIF20A, PVT1 and TIMP1, while low expression of ADACSB, DPEP and MT1G. The results of the KM survival curves suggested that ccRCC patients with high-risk scores had a significantly lower probability of survival than those with low-risk scores (Fig. 2E). Here, PVT1 is linked to nonpapillary renal cell carcinoma.