Tumor-derived Gal-1 has been revealed to boost the proliferation and metastasis of gastric cancer cells via the neuropilin-1/c-JUN/Wee1 pathway [152] and enhance nanoclustering of the H-Ras proto-oncogene through direct interaction with the Ras binding domain of Raf [153]. The gene discussed is LGALS1; the disease is gastric cancer.