LGALS1 and neoplasm: In this regard, the role of Gal-1 in fibroblast growth factor (FGF)−FGFR interaction and FGFR clustering [143, 144] is particularly important since Gal-1 expression is the highest in fibroblasts in almost all tissues, and FGFR amplification, mutations, fusions, or rearrangements can activate many pathways that lead to tumor development [145].