SOD2 and posterior cortical atrophy: Chaiswing et al. observed a significant increase in the expression of manganese superoxide dismutase (MnSOD) and thioredoxin 1 (TRX1) in PCa tissues, but MnSOD activity increased only slightly (enzyme activity increased 0.5-fold, while protein expression increased twofold), and TRX1 activity remained unchanged.