RNF112 and bladder transitional cell carcinoma: Moreover, wound healing assays and transwell migration assays were used to investigate the effect of RNF112 on the metastatic ability of BLCA cells, and the results revealed that overexpression of RNF112 inhibited the metastasis of BLCA cells, whereas knockdown of RNF112 promoted metastasis (Figure 2G–J; Figure S2F–I, Supporting Information).