MYC and bladder transitional cell carcinoma: Studies have reported that nearly all patients with locally advanced BLCA exhibit MYC amplification,[19] and early‐stage BLCA with abnormally high MYC expression is associated with a higher recurrence rate.[20] Owing to the lack of an enzymatic pocket, c‐Myc is difficult to target with small‐molecule drugs.[21] Given the importance of c‐Myc in BLCA and its degradation via the ubiquitination pathway, exploration of E3 ligases upstream of c‐Myc has been ongoing.