The results confirmed that simultaneous overexpression of c‐Myc and RNF112 rescued the inhibitory effect of RNF112 on the proliferation and migration of T24 and 5637 cells (Figure 6A,B; Figure S8A,B, Supporting Information), whereas simultaneous knockdown of RNF112 and c‐Myc attenuated the promoting effect of RNF112 knockdown on the proliferation and migration of BLCA cells (Figure 6C,D; Figure S8C,D, Supporting Information). Here, RNF112 is linked to bladder transitional cell carcinoma.