Previous studies have reported that the transcription factor c‐Myc plays a critical role in regulating lipid metabolism.[14] On the basis of our findings and previous studies,[25] we selected several representative key enzymes and transcription factors (SREBF1, ACLY, HMGCR, HMGCS1, ACACA, FASN, SCD1, CPT1A, and CPT1B) associated with lipid metabolism for subsequent studies and found that only the mRNA expression of ACLY significantly decreased after the overexpression of RNF112 in BLCA cells. This evidence concerns the gene HMGCS1 and bladder transitional cell carcinoma.