ACLY and cancer: Lipid metabolism reprogramming is a common occurrence in aggressive tumors, such as BLCA, where essential lipid synthesis enzymes such as ACLY and FASN are upregulated.[26] Lipid droplets are unique intracellular organelles that not only store energy but also relieve endoplasmic reticulum stress and lipotoxic stress.[27] Therefore, targeting lipid synthesis in tumors is considered a promising cancer therapeutic strategy.