Especially compared with systemic anti‐PD‐L1 immunotherapy, the locoregional PD‐1/PD‐L1 blockade and immunomodulation of TDLN by EmDEX@GA exhibited more effective suppression on LNM and DM, which indicated the essential role of TDLNs in tumor progression and metastasis apart from TME. The gene discussed is CD274; the disease is neoplasm.