STING pathway is an essential regulator of anti‐tumor immunity.[33] The activation of STING pathway promotes the production of type I interferons (IFN‐α and IFN‐β), which are benefit for DC maturation and its ability of antigen presentation, as well as T cells recruitment and infiltration.[34, 35] After constructing the expected engineered exosomes, we established the orthotopic mouse model of breast cancer that would occur LNM and DM over time. The gene discussed is STING1; the disease is breast cancer.