Immunosuppressive ligand programmed death‐ligand 1 (PD‐L1) was highly expressed on DCs in TDLNs from both patients and mouse model.[12, 13] Meanwhile, specific blockade of DC‐derived PD‐L1 improved T cell activation and anti‐tumor immunity.[12, 14, 15, 16] The binding of PD‐L1 and programmed cell death protein 1 (PD‐1) is usually known to take place in tumor microenvironment (TME) to induce immune evasion. Here, CD274 is linked to neoplasm.