PDCD1 and neoplasm: While intratumoral injection, EmDEX@GA achieved dual accumulation in TME and TDLNs, performed immune microenvironment remodeling via the synergistic effects of PD‐1/PD‐L1 blockade and STING‐mediated immunocytes activation, subsequently enhanced anti‐tumor immunity and further suppressed tumor progression and metastasis.