GSDMD and neoplasm: Due to their enhanced permeability and retention characteristics, nanoparticle‐based tumor‐targeted delivery systems can achieve the targeted delivery and release of siRNAs in tumors, making them excellent carriers for precise in vivo siRNA delivery.[48] In our study, we further utilized pH‐responsive nanoparticles loaded with a GSDMD siRNA in the tumor microenvironment to successfully knock down GSDMD expression and inhibit tumor metastasis in in vitro and in vivo models.