GSDMD and neoplasm: We designed wild‐type GSDMD (wt), GSDMD cleavage site mutant (mut), GSDMD‐C‐terminal (C), N‐terminal with membrane‐binding domain mutant (MCD), and N‐terminal cytotoxic domain (CD) plasmids (Figure 5A) to determine which domain of GSDMD regulates MMP14 expression and tumor metastasis in OSCC.