Considering this mechanism and the ability of small interfering RNAs (siRNAs) to silence the expression of any target gene,[22, 23, 24] we further developed pH‐responsive nanoparticles (NPs) for the systemic codelivery of a cisplatin prodrug and GSDMD siRNA (siGSDMD) and showed that this codelivery system could effectively inhibit OSCC tumor growth and metastasis with reduced toxicity and side effects (scheme). This evidence concerns the gene GSDMD and neoplasm.