HER2+ was reported for three tumors: an IHC 3+ tumor harboring ERBB2 V777L with ERBB2 co-amplification, an IHC 3+ tumor with D769Y + G776V and co-amplification, and an IHC 2+/FISH+ tumor with an Ex19Del (L755_T759del) which was non-amplified. The gene discussed is ERBB2; the disease is neoplasm.