Other interesting observations included the mutual exclusivity of KEAP1 and STK11 in NSCLC (Supplementary Fig. S8A) and enrichment for CDH1, PIK3CA, and ARID1A along with mutual exclusivity with BRCA1/2, PTEN, and ESR1 in breast cancer (Supplementary Fig. S8B). The gene discussed is ESR1; the disease is non-small cell lung carcinoma.