Prompted by our cyclin D1 findings, we rephenotyped VHL−/− ccRCC lines and discovered that the proliferation of TUHR14TKB cells, although annotated to be HIF2-dependent (24), was unaffected by PT2399 or CRISPR-mediated elimination of HIF2α (Supplementary Fig. S15A–S15D). This evidence concerns the gene EPAS1 and nonpapillary renal cell carcinoma.