CCND1 and nonpapillary renal cell carcinoma: In support of a noncanonical cyclin D1 function, however, both WT cyclin D1 and the cyclin D1 K112E variant promoted PT2399 resistance in the TKO ccRCC cells, as measured by cell number (Fig. 5C–E; Supplementary Fig. S10C, S10D, S11C, and S11D) and G/1S progression (Supplementary Fig. S7C–S7F).