APOE and triple-A syndrome: The development and progression of AAA were also accelerated markedly in ecCNP−/−/ApoE−/− mice and ecCNP−/− mice administered AAV.mPCSK9D377Y typified by increased aortic diameter (Figure 3D and 3E; Figures S3 and S5) independent of changes in blood pressure (Tables 3 and 4), supporting our earlier observations that endothelial CNP is protective in AA.13 This was accompanied by a significant reduction in both NPR-B and NPR-C mRNA abundance in abdominal aorta of Ang II–infused ecCNP−/−/ApoE−/− compared with WT mice (Figure 3F).