CNP and triple-A syndrome: Indeed, the fact that CNP deletion aggravated disease severity in both ascending and abdominal regions suggests that the common pathways governed by the peptide are at play in both TAA and AAA, despite the well-validated differences in etiology.5,46 This also bodes well for therapeutically targeting CNP-driven pathways in subpopulations of patients with AA since it hints that patient stratification might not be necessary.