CNP and triple-A syndrome: Mirroring these findings and observations in human tissue, Ang II infusion upregulated an analogous panel of genes involved in inflammation, fibrosis, apoptosis, ECM remodeling, and calcification in the abdominal aortic region (Figure 1G; Figure S1B); these data also dovetail well with previous work using this model.4,27 Akin to observations in human aneurysmal tissue, in murine AAA, CNP mRNA abundance was increased but NPR-B and NPR-C mRNA was reduced significantly (Figure 1H).