Although there was no significant change in basal diameter of the abdominal aorta between NPR-C−/−/ApoE−/− and ApoE−/− (control) mice, Ang II infusion accelerated the development and progression of AAA, with a similar profile in gene expression to the ascending aorta (Figure 5D and 5E; Figure S3). Here, AGT is linked to triple-A syndrome.