CNP and Marfan syndrome: To establish the key cognate NPRs that underpinned the protective actions of CNP to offset TAA and AAA development, we utilized mice with a global NPR-C deletion.12–14,28,33 Interestingly, NPR-C−/− mice have an elongated stature and long digits at baseline, a phenotype that mirrors MFS patients, hinting at a pathogenic connection.