A total of 16,149 genes positively related to METTL3 (R > 0.3, p < 0.0001) according to TCGA CRC data through the cBioPortal database were analyzed using R software, package “ggplot2” to further elucidate the GO enrichment analysis as shown in Figure 6. This evidence concerns the gene METTL3 and colorectal carcinoma.