CENPE and cancer: Tamaoki et al. developed a photoswitchable inhibitor based on azopyrazole that targets CENP-E and showed reversible control of CENP-E activity in cancer cells by UV light exposure with a 10-fold difference in inhibition activity between trans and cis isomers (Fig. 6b).97 This study highlights the potential of a photochemical approach for precisely controlling mitotic interference and uncovering specific molecular functions in dynamic cellular processes.