POU5F1 and neoplasm: Examples include CD44 and CD133 (self-renewal), SRY homology box 2 (SOX2) (proliferation and progression), and markers of tumor initiation, such as histone 3 lysine 4 methyl transferase 2 (MLL2) and G protein-coupled receptor family C group 5 member A. Among these, OCT4 is a particularly significant marker.