Immune cells within the TME, such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), further promote resistance by inhibiting cytotoxic T lymphocyte (CTL) and natural killer (NK) cells activity through the release of immunosuppressive cytokines, including interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β). The gene discussed is TGFB1; the disease is neoplasm.