TF and Iron deficiency anemia: It is well documented that disruptions in functional elements of the dopaminergic system, which eventually affect tonic/phasic dopaminergic signalling, may occur in combination with iron deficiency.28 Decreased D1 and D2 receptors,32,104 and also reduced brain iron, ferritin and transferrin concentrations,105 in response to systemic iron deficiency have been documented in rat experiments.