In NOT rule eligible patients and in those with a maximum hs-TnT >5 and <14 (n = 154), IGFBP-3 with ΔIGFBP-3 improved the prediction of 70% coronary artery stenosis over clinical variables (ΔAUC 0.03, 95% CI −0.01 to 0.06, and 0.04, 95% CI 0.002–0.10) (Table 2). The gene discussed is IGFBP3; the disease is coronary stenosis.