Shenzhu tiaopi granule (SZTP) can increase the relative abundance of Lactobacillus in the intestines of T2DM rats, reduce the relative abundance of Allobaculum and Desulfovibrionaceae, improve blood glucose and lipid levels in T2DM rats (Zhao J. et al., 2019), decrease LPS and IL-1β levels, increase the abundance of Intestinimonas, reduce the abundance of Eubacterium coprostanoligenes, regulate bile acid biosynthesis and cholesterol metabolism, and alleviate hyperglycemia (Zhao and Fang, 2024). The gene discussed is IL1B; the disease is type 2 diabetes mellitus.