NFIL3 and fatty liver disease: Targeted knockout of the NFIL3 gene significantly enhances the activity of adenosine monophosphate-activated protein kinase (AMPK) in the liver and increases the abundance of the AMPK β1 subunit, thereby improving hepatic steatosis and liver function in mice (Wang et al., 2023; Yang et al., 2020; Wu et al., 2024).