Additionally, injecting adipose-derived mesenchymal stem cells (ADSC) into chronic mild stress (CMS)-induced depressed mice results in ameliorated depressive behaviors and elevated levels of PEBP1 and GPX4 in the hippocampus, indicating that PEBP1 may serve as a bridge linking the pathogenesis of depression with ferroptosis. The gene discussed is PEBP1; the disease is major depressive disorder.