In the LPS-induced depression model, the demethylation function of m6A-modified PRMT2 mRNA is inhibited, resulting in increased expression of PRMT2 in BV2 cells and the hippocampus, while ALKBH5, SLC7A11, and GPX4 expressions decrease, facilitating ferroptosis. The gene discussed is ALKBH5; the disease is depressive symptom measurement.