Moreover, MFN2 plays a role in cell proliferation, apoptosis, and autophagy, contributing to fibroproliferative diseases (such as pulmonary fibrosis, cirrhosis, and cardiovascular fibrosis), atherosclerosis, pulmonary hypertension, tumors and other diseases (Xin et al., 2021). Here, MFN2 is linked to pulmonary fibrosis.