Multivariate logistic regression analysis identified age (OR 1.05, 95% CI [1.02–1.07], P < 0.01), BMI (OR 0.92, 95% CI [0.86–0.98], P < 0.01), stroke (OR 2.21, 95% [1.43–3.42], P < 0.01), ARDS (OR 4.0, 95% CI [2.17–7.37], P < 0.01), AKI (OR 2.98, 95% CI [1.77–5.01], P < 0.01), malignancy (OR 2.11, 95% CI [1.22–3.65], P < 0.01), elevated WBC (OR 1.20, 95% [1.14–1.27], P < 0.01), PLT (OR 0.995, 95% CI [0.993–0.998], P < 0.01), and albumin (OR 0.93, 95% CI [0.90–0.97], P < 0.01) as independent risk factors for in-hospital mortality. This evidence concerns the gene ALB and acute kidney injury.