In most cases, this includes genes involved in kidney development, which only adds to the overall embryonic explanation of nephroblastoma formation – for example WT1, WT2, the IGF2 region, the WNT pathway, MYCN, WTX, CTNNB1, and TP53. Recently discovered ones include miRNA processing genes and the transcription factors SIX1/2 (3–5, 7, 19–23). The gene discussed is TP53; the disease is Wilms tumor.