This involves increases in immune-related gene expression and decreases in the expression of certain synaptic genes, such DNM1, SYN1, SYN2. For example, mutations in the DNM1 gene can contribute to neurological dysfunction, including ataxia-like symptoms, due to its critical role in synaptic vesicle recycling and membrane trafficking in neurons. The gene discussed is DNM1; the disease is Ataxia.