On the model of human neuroblastoma SH-SY5Y with D-gal (or different concentrations of beryllium salts), there were increased numbers of aging markers such as p16 and p21 as well as the SA-β-gal activity.The effect of T1-11 (an adenosine analog) on adenosine receptor A2AR activation was investigated. It was suggested that A2AR activity would reduce cellular senescence, which was confirmed by a decrease in p16, p21 and SA-β-gal levels in SH-SY5Y with higher concentration of T1-11. Here, CDKN2A is linked to neuroblastoma.