While literature reports suggest that MiT/TFE tRCC rarely displays Ksp-cadherin, a marker commonly used in diagnosing chromophobe RCC, the co-expression of these markers in this case may imply a more aggressive biological behavior akin to chromophobe RCC (10). Here, CDH16 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.