At the immunohistochemical level, the overexpression of genes such as murine double minute 2 (MDM2), Cyclin dependent kinase 4 (CDK4), Cyclin dependent kinase inhibitor 2 (P16) and vimentin in the multiple dedifferentiated zones are highly sensitive markers for the diagnosis of DDLPS, allowing us to differentiate it from other types of soft tissue sarcoma [3]. Here, CDK4 is linked to dedifferentiated liposarcoma.