In addition, Brown C.W. et al. Reported that treatment with the ferroptosis inducer RSL3 enhances the expression of PROM2, a pentaspanin protein involved in lipid dynamics and membrane structure, which promotes the formation of MVBs and EVs responsible of transporting iron-rich ferritin out of mammary epithelial and breast cancer cells. The gene discussed is PROM2; the disease is breast carcinoma.