It is to mention that Arg-II-induced suppression of Sirt3 is independent of mtROS in the tumor cells, since inhibiting mtROS with TEMPO does not affect Sirt3 levels, demonstrating that there is no mutual regulation between Sirt3 and mtROS and the enhanced mtROS is due to suppression and Sirt3. The gene discussed is SIRT3; the disease is neoplasm.