In supporting the notion that multi-lobed nuclei are associated with higher migration activity (Pfeifer et al., 2019; Mierke, 2019; Das et al., 2019), our results from the trans-well migration assay showed that, compared with the control group, a greater number of arg-ii-overexpressing tumor cells passed diameter-restricted holes in the membrane, demonstrating that the Arg-II-mediated mtROS through suppressing Sirt3 induces nuclear deformation, leading to enhanced migration of the cancer cells. The gene discussed is SIRT3; the disease is cancer.